生物谷报道：在细胞生物学的教科书中有两个关于高尔基网络成熟过程的模型：在“传统模型”中，含有“货物”蛋白的小囊在“生产线”上从一个囊运动到另一个囊，沿途它们被修饰，直到其被分泌出来；而“囊泡成熟模型”（囊泡是平坦的、盘状膜囊，包括高尔基分泌系统在内）认为，一个单一的高尔基腔室随着时间的推移而发育，使得“货物”蛋白始终留在一个囊泡中，直到它们做好了被包裹进“运送”囊中、运送到其最终目的地为止。两个独立的研究小组利用尖端成像技术发现，在酿酒酵母中，这些蛋白在被分泌之前始终留在一个囊泡中。这一研究成果发表在六月22日出版的Nature上。
Tier I shows budding from ER that is arranged facing a central zone at one end of the Golgi complex. These buds become vesicles and are coated with COPII protein coats.
As you will recall from a previous presentation on rough endoplasmic reticulum we saw that they are inserted in the membrane at the level of the rough endoplasmic reticulum. The protein sequence is coded for membrane insert start and stop sites. This directed the insertion and alignment points. Those that are multipass proteins have multiple start and stop sites.
The Golgi complex is compartmentalized. Phosphorylation occurs in the Cis region. In other regions, different types of carbohydrates are added as a glycoprotein passes through the cisternae. This figure illustrates the different regions where sugars like mannose (man), galactose (gal), etc are added. The final sorting is done in the Trans Golgi complex.
Sometimes vital proteins needed in the rough endoplasmic reticulum are transported along with the other proteins in the Golgi complex. The Golgi complex has a mechanism for trapping them and sending them back to the rough endoplasmic reticulum.
个体化医疗是未来医学研究与应用的趋势，而个体化治疗的关键在基于生物分子标志物的诊疗策略
中国疫苗市场的巨大潜力，吸引了世界排名最领先的跨国疫苗制造巨头前来淘金。
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